Exploring the functional structure of the retIna with closed loop stimulation. A physiological and computational approach.

About the Project

This project aims to better understand the retina’s response to complex visual stimuli and unravel the role played by the lateral inter-neurons network (amacrine cells) in this response. For this, we will adopt an experimental methodology using real-time control and feedback loop to adapt, in real-time, visual stimulations to recorded retinal cell responses. The experiments will be done in Valparaiso (Chile). The Biovision team will develop the control software and extrapolate results at Inria Sophia-Antipolis based on its recent theoretical advances in retina modelling. This is, therefore, a transdisciplinary and international project at the interface between biology, computer sciences and mathematical neurosciences. Beyond a better understanding of its network structure’s role in shaping the retina’s response to complex spatiotemporal stimuli, this project could potentially impact methods for diagnosing neurodegenerative diseases like Alzheimer’s.

Principal Investigator
  • Bruno Cessac, Inria Biovision
Project's partner(s)
  • Adrian Palacios, Valparaiso University, Center of Neuroscience, Valparaiso, Chili
Duration
  • June 2023 - December 2024
Total Amount
  • 18 000 euros
Publications
1. « Closed loop strategy to characterize the retinal network: preliminary steps », B. Cessac, S. Ebert, M.J. Escobar, F. Miqueles, A. Palacios, E. Petit, J. Portal-Diaz, Inria research report. In progress.

2. « Parameters estimation in a retinal network model », B. Cessac, L. Pronzato, L. Sacchelli. Article in progress.

3. « On the retinal response to a moving bar », B. Cessac, S. Ebert, L. Piovano, Article in progress.

4. «Temporal refinement of spatiotemporal pattern prediction via short-term plasticity», B. Cessac, S. Ebert, Article in progress.
Leveraged projects
Associated team: Inria FUSION  https://team.inria.fr/biovision/fusion-functional-structure-of-the-retina-a-physiological-and-computational-approach/